By China) International Symposium on Plant Glycosides (1997 Kunming, Chong-Ren Yang, Osamu Tanaka, Chong-Ren Yang, Osamu Tanaka
Within the plant nation a number of chemical ingredients take place in a glycoside shape (conjugation with sugar). Glycosides are very important, secondary metabolites. The structural variety is as a result of the substantial volume of sorts and stereochemical configurations of the sugar part. Aglycones belong to terpenoid, steroid, flavonoid, quinonoid, lignan, different easy phenolics, and isothiocyanate. even though, organic actions of glycosides are, in lots of instances, at risk of the character of sugar moieties, although their aglycone is the same.
Since the 80s, plant glycosides were attracting an expanding quantity of curiosity from botanists and phytochemists world-wide for the next reasons:
вЂў they're tough to isolate and purify
вЂў they've got a crucial organic functionality in vegetation and memorable organic activities
вЂў they seem to be a extremely important source of usual drugs, wellbeing and fitness meals, cosmetics and f
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Additional info for Advances in plant glycosides, chemistry and biology: proceedings of the International Symposium on Plant Glycosides, August 12-15, 1997 Kunming, China
The method of in vivo two-stage carcinogenesis test on mouse skin tumor is shown in Figure. (85 nmol) inacetone OMBA(390nmol)l l tPA(l'7nm~ 1 [ I [ tPA(l~[ "7nrn~/ i test I h,. I P o s t - T r e a t e d Group I I twice a week test eomp. (85 nmol) in a c e t o n e o. , I/ I I twicea week 20 weeks _1 rI Figure 2. Method of In vivo Two-Stage Carcinogenesis Test on Mouse Skin Tumor As shown in Figure 2, the inhibitory effects of the MeOH extract of P. notoginseng on two-stage carcinogenesis of mouse skin tumor under pre-treatment and post-treatment, using dimethylbenz- [a]anthracene (DMBA) as an initiator and TPA as a promoter, were investigated.
Chart 4. Structure of Oleanolic Acid Glycosides 24 -,~ _=v 0 O - CH OHI OH activity alter a single oral administration if 100 mg/kg. Since oleanolic acid (38) lacked the inhibitory activity, the 3-O-glycosede moiety of those glycosides was found to be essential for exerting the activity, Among oleanolic acid 3, 28-bisdesmosides, betavulgarosides I (1), III (3), and V (5) and related glycosides (39, 42) showed no activity, while chikusetsusaponin IV(41), which possessed an o-L-arabinofuranosyl moiety at the 4'-position of the glucuronic acid part, exhibited the inhibitory activity.
3-A) and the average number of papillomas per mouse (Fig. 3-B) of treated group were compared with those of the positive control group. In the positive control group, 80% of mice bore papillomas at 8 weeks of promotion and 100% of mice bore papillomas at 10 weeks of promotion, and more than 10 papillomas were formed per mouse atter 20 weeks of promotion. In the group pre-treated with the extract of P. notoginseng, only about 45% of mice bore papillomas at 10-12 weeks of promotion, and only 5 papillomas were formed per mouse atter 20 weeks of promotion.